2009•Chinese Journal of Hospital PharmacyRequires access
Effect of ligustrazine on NO and iNOS in rats with acute kidney injury induced by paraquat
Yanyan Zhao
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Abstract
OBJECTIVE The variance of NO and iNOS in rats with acute kidney injury induced by paraquat was investigated,and the protection of ligustrazine in rat acute kidney injury was approached.METHODS 50 Sprague-Dawley (SD) rats were randomly divided into five experimental groups:blank group,negative control group,positive control group,ligustrazine low-dose group(LDG),ligustrazine high-dose group(HDG).Macroscopic and histopathological examinations were performed.In the mean time,the level of BUN、Cr、MDA、SOD and GSH-Px in plasma were detected,and the activities of kidney tissue homogenate NO and iNOS were measured.RESULTS Compared with that in negative control group,hemorrhage of kidney of ligustrazine low-dose group were mitigated.And BUN、Cr、MDA、SOD、GSH-Px 、NO and iNOS in plasma have significant difference (P0.01).CONCLUSION NO and iNOS could play an role in kidney injury of poisoned rats.ligustrazine could ameliorate the kidney injury and decrease the concentrations of NO and iNOS.