2013•Chinese Journal of Birth Health & HeredityRequires access
Analysis of chromosomal karyotypes in 1950 cases of genetic counseling in Zaozhuang.
Gan Xin-hu
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Abstract
Zaozhuang 1950 cases genetic counseling′s peripheral blood cell culture,conventional preparation of chromosome and G banding karyotype were analysed.It was found 175 cases abnormalities,abnormalities frequency for 8.97%(175/1950),abnormal karyotype involves trisomy,haplotype,Robertsonian translocation,and unbalanced rearrangement.1125 cases of adverse pregnancy history subjects,detected abnormal karyotype 89 cases,accounting for abnormal karyotype 51%(89/175),and varying degrees of mental retardation 356 cases,detected abnormal karyotype 54 cases,accounting for abnormal karyotype 31%(54/175),infertility 469 cases,abnormal karyotype 32 cases,accounting for 18% of the abnormal karyotype(32/175).Karyotype analysis for adverse pregnancy history,mental retardation,infertility,disease diagnosis is important,and interrelate to D,G group of the short arm of variation,and the length of the Y chromosome variation,these should cause clinical attention.