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Expression of HIF-2α in non-small cell lung cancer (NSCLC) and its relationship with VEGF

Tiecheng Pan

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Abstract

Objective:To study the expression of HIF-2α gene and its relationship with VEGF protein in non-small cell lung cancer.Methods:Immunohistochemical method was used to examine the expression of HIF-2α and VEGF in 45 cases of NSCLC tissue section.Results:Positive HIF-2α and VEGF expression was detected in 77.78% and 75.56% of 45 cases of NSCLC tissue section,HIF-2α expression was not detected and VEGF expression was only 1 positive of 10 cases of normal lung tissue.No relation with tumor differentiation,tumor size (P0.05).Histopathological type,lymph node metastasis and TNM stage correlated with the expression of HIF-2α and VEGF(P0.05).HIF-2α level positively correlated with VEGF level (P0.01).Conclusion:The detection of VEGF and HIF-2α play an important role in prognosis and treatment of NSCLC.

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What this paper is about

Objective:To study the expression of HIF-2α gene and its relationship with VEGF protein in non-small cell lung cancer.Methods:Immunohistochemical method was used to examine the expression of HIF-2α and VEGF in 45 cases of NSCLC tissue section.Results:Positive HIF-2α and VEGF expression was detected in 77.78% and 75.56% of 45 cases of NSCLC tissue section,HIF-2α expression was not detected and VEGF expression was only 1 positive of 10 cases of normal lung tissue.No relation with tumor differentiation,tumor size (P0.05).Histopathological type,lymph node metastasis and TNM stage correlated with the expression of HIF-2α and VEGF(P0.05).HIF-2α level positively correlated with VEGF level (P0.01).Conclusion:The detection of VEGF and HIF-2α play an important role in prognosis and treatment of NSCLC.

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Available abstract

Objective:To study the expression of HIF-2α gene and its relationship with VEGF protein in non-small cell lung cancer.Methods:Immunohistochemical method was used to examine the expression of HIF-2α and VEGF in 45 cases of NSCLC tissue section.Results:Positive HIF-2α and VEGF expression was detected in 77.78% and 75.56% of 45 cases of NSCLC tissue section,HIF-2α expression was not detected and VEGF expression was only 1 positive of 10 cases of normal lung tissue.No relation with tumor differentiation,tumor size (P0.05).Histopathological type,lymph node metastasis and TNM stage correlated with the expression of HIF-2α and VEGF(P0.05).HIF-2α level positively correlated with VEGF level (P0.01).Conclusion:The detection of VEGF and HIF-2α play an important role in prognosis and treatment of NSCLC.

Key concepts: Immunohistochemistry, VEGF receptors, Lung cancer, Stage (stratigraphy), Medicine, Pathology, Lung, Vascular endothelial growth factor

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