Expression of HIF-1α and VEGF in non small cell lung cancer and relationship between them and tumor angiogenesis

To investigate the relationship between the expression of HIF-1α, VEGF and tumor angiogenesis in non small cell lung cancer(NSCLC). The expression of HIF-1α, VEGF and MVD were evalulated by immunohistochemical method. The expression of HIF-1α and VEGF in NSCLC tissue was demonstrated in 71.11% and 66.7%, respectively, and significantly higher than that of normal lung tissue (P0.05); there was a statistically significant correlation between HIF-1αexpression and lymph node metastase, TNM stages,VEGF expression and MVD; But no significant corerelation was seen between HIF-1αexpression and tumor size, pathological grade,; there was also a statistically significant correlation between VEGF expression and tumor size, lymph node metastase, pathological grade ,TNM stages and MVD. [Conclusion] The present finding suggests that the expression of HIF-1α,VEGF correlates closely with tumor invasion and angiogenesis.