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Improvements on Surgical Model Techniques of Rat Orthotopic Liver Transplantation

Hongxian Yan

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Abstract

Objective To improve some surgical model techniques of rat orthotopic liver transplantation.Methods Two-cuff(portal vein and infrahepatic vena cava) technique was applied to the production of the animal model in SD and Wistar rats.Results With the improvements a successful rate of 85% was achieved in the production of the experimental model with anhepatic period of an average 21 minutes.Conclusion The results show that the model is stable and can be used in the experiment of liver transplantation in the rats.

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Objective To improve some surgical model techniques of rat orthotopic liver transplantation.Methods Two-cuff(portal vein and infrahepatic vena cava) technique was applied to the production of the animal model in SD and Wistar rats.Results With the improvements a successful rate of 85% was achieved in the production of the experimental model with anhepatic period of an average 21 minutes.Conclusion The results show that the model is stable and can be used in the experiment of liver transplantation in the rats.

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Available abstract

Objective To improve some surgical model techniques of rat orthotopic liver transplantation.Methods Two-cuff(portal vein and infrahepatic vena cava) technique was applied to the production of the animal model in SD and Wistar rats.Results With the improvements a successful rate of 85% was achieved in the production of the experimental model with anhepatic period of an average 21 minutes.Conclusion The results show that the model is stable and can be used in the experiment of liver transplantation in the rats.

Key concepts: Medicine, Portal vein, Orthotopic liver transplantation, Animal model, Rat model, Liver transplantation, Transplantation, Cuff

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