Effects of Xueshuantong injection combined with benazepril on renal pathological changes of diabetic nephropathy and on h-CRP and TNF-α expression

Objective To observe the protective effects on diabetic nephropathy(DN) rats by Xueshuantong injection combined with benazepril and to explore its therapeutic mechanism.Methods DN rat models were prepared by high-glucose and high-fat forage added with small-dose STZ.The rats were randomized into DN group without intervention(DN group),DN with benazepril group(B group),DN with benazepril and Xueshuantong injection group(X group) and normal group(N group).The level of h-CRP and TNF-α expression was measured at the end of 12th week.The renal pathomorphologic changes were observed.Results The level of h-CRP and TNF-α expression in X group obviously decreased as compared with that in DN group(P0.01).The level of h-CRP and TNF-2 expression in X group significantly decrensed as comparerd with that in B group.Gromeralor basement membrane thickening and mesangial cell proliferative lesions were significantly improved.Conclusion Xueshuantong injection combined with benazepril can significantly protect DN rat's kidney,which might be its mechanism of reducing h-CRP and TNF-α expression and inhibiting the DN proliferation of mesangial matrix and deposition of extracellular matrix.