2013•Unpublished venueRequires access
Effects of Xueshuantong injection combined with benazepril on UAER and TGF-β1 expression in diabetic nephropathy rats
Jiang Hongwei
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Abstract
Objective To explore the protective effects of Xueshuantong injection combined with benazepril on diabetic nephropathy(DN) and to explore its therapeutic mechanism.Methods Sixty healthy SD rats were randomized into normal group,DN group,benazepril group,benazepril+Xueshuantong group.DN rat models were induced by a high-glucose and high-fat diet and a small-dose of STZ.The urinary albumin excretion rate(UAER) and TGF-β1 expression were measured at the end of 12 weeks.Results UAER and TGF-β1 expression in DN group obviously increased as compared with normal group(P0.01).UAER and TGF-β1 expression in benazepril+Xueshuantong group significantly decreased as compared with DN group(P0.05 or 0.01).UAER and TGF-β1 expression in benazepril+Xueshuantong group significantly decreased as compared with benazepril group(P0.05 or 0.01).Conclusion Xueshuantong injection combined with benazepril can significantly have a protective effect on the DN kidney by reducing UAER and decreasing TGF-β1 expression in renal tubuale and glomerulus.