Effects of Angelica parenteral Injection on Hemodynamics in Experimental DIC Rats

Objective To explore the effects of Angelica parenteral Injection(APS) on hemodynamics in rats with disseminated intravascular coagulation(DIC).MethodsA model of DIC was made in rats by Dextran500 injection from jugular vein,and effects of APS on micro-vessels,micro-area blood flow volume of organs,blood viscosity and platelet aggregation were studied in rats by an observation of mesenteric microcirculation,determination of hemorheology and blood flow volume.ResultsThe microcirculation disturbance was mainly micro-vessels contraction,slow micro-blood flow and micro-thrombus after Dextran 500 injection.The result showed that APS could dilate micro-vessel obviously and reduce multiple score values of blood flow and blood cell aggregation,there were obvious differences compared with normal saline(NS) group(P0.05).The micro-area blood flow volume of stomach,intestine and liver was evidently increased in APS and NS groups,however,the former effect was superior to NS group(P0.05).After treatment with APS,the blood viscosity and platelet aggregation were obviously lower than those of NS group,and meantime the deformity ability of RBC was obviously increased(P0.05).ConclusionAPS can influence the recovery of DIC through dilating micro-vessel,increasing blood flow volume of organs,and reducing blood viscosity and platelet aggregation.