Effects of Gustrazine and Angelica Parenteral Solution on Palelet Function and Blood Flow Volume of Organs in Rats with Acute Microcirculation Disturbance

Objective: To explore effects of gustrazine and angelica parenteral solution on palelel function and blood flow volume of organs in rats with acute microcirculalion disturbance from an angle of microcireulation, hemorheology and blood flow volume of organs. Methods: A acute microcirculation disturbance model was made by jugular vein Dextran500 injection in rats, and the interferential effect of gustrazine and angelica parenteral solution on palelet function and blood flow volume of organs was studied in 18 rats by an observation of mesenteric microcirculation and determination of hemorheology and blood flow volume. Results: The microcirculalion disturbance was mainly micro-vessels contraction, slow micro -blood flow and micro -thrombus after Dextran 500 injection, after treatment of gustrazine and angelica parenteral solution, the multiple score values of blood flow and micro-thrombus, rates of patelet adhesive and aggregation were lower than that of normal saline (NS) group (p0.05). The micro-region blood flow volume of stomach, intestine and liver was evidently increased in three NS groups, however, the effect of gustrazine and angelica parenteral solution was superior to NS group (p0.05). Conclusion: Gustrazine and angelica parenteral solution can influence the recovery of acute microcirculalion disturbance induced by Dextran 500 through improved microcirculation, increased blood flow volume of organs, reduced blood viscosity and palelet aggregation.