Observation effect of leflunomide combined with glucocorticoids in comparison with cyclophosphamide glucocorticoid therapy on IgA nephropathy

Objective: To investigate the treatment clinical efficacy of leflunomide combined with glucocorticoids for IgA nephropathy and compared cyclophosphamide glucocorticoid therapy clinical effects of the disease.Methods: Thirty patients with IgA nephropathy were randomly divided into two groups of 15 cases labeled as the control group and the observation group.And the control group were treated with cyclophosphamide combined with corticosteroids,whilte the observation group were treated with leflunomide combined sugar corticosteroid therapy,and the therapeutic effect of two groups were compared.Results: In the control group,the effective rate of patients was 65.0%,while in the observation group it was 75.0%,and the difference was no statistically significant(P 0.05);the control group overall rate of adverse reactions was 50.0%,while the observation group was 15.0%,and the difference was statistically significant(P 0.05).Conclusion: IgA nephropathy leflunomide is safe and effective,and it is more effective than cyclophosphamide,which is worthy of clinical application.