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2005•Journal of Sun Yat-sen UniversityRequires access

Effect of Leflunomide in Treatment of IgA Nephropathy

Chenggang Shi

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Abstract

【Objective】 To investigate the effect and safety of leflunomide in treatment of IgA nephropathy.【Methods】Fifty-eight IgA nephropathy patients were divided into two groups at random. The patients in test groupreceived leflunomide treatment; the patients in control group received fosinopril. Clinical data were observed andevaluated in the 2nd, 4th, 6th, 8th, 12th, 16th, 20th, 24th, and 28th weeks. 【Results】 After receivingleflunomide therapy, the proteinuria in the test group decreased significantly (P 0.05) ; serum albumin increasedsignificantly (P 0.05) . The complete relieving rate was 61%; the total efficient rate was 71%. Contracted with fosinopril, the efficiency of leflunomide on treating IgA nephropathy was not statistically different (P 0.05). Theside effects were mild, and all patients tolerated this the rapy.【Conclusion】Leflunomide is one of the choices in treating IgA nephropathy .

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【Objective】 To investigate the effect and safety of leflunomide in treatment of IgA nephropathy.【Methods】Fifty-eight IgA nephropathy patients were divided into two groups at random. The patients in test groupreceived leflunomide treatment; the patients in control group received fosinopril. Clinical data were observed andevaluated in the 2nd, 4th, 6th, 8th, 12th, 16th, 20th, 24th, and 28th weeks. 【Results】 After receivingleflunomide therapy, the proteinuria in the test group decreased significantly (P 0.05) ; serum albumin increasedsignificantly (P 0.05) . The complete relieving rate was 61%; the total efficient rate was 71%. Contracted with fosinopril, the efficiency of leflunomide on treating IgA nephropathy was not statistically different (P 0.05). Theside effects were mild, and all patients tolerated this the rapy.【Conclusion】Leflunomide is one of the choices in treating IgA nephropathy .

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Available abstract

【Objective】 To investigate the effect and safety of leflunomide in treatment of IgA nephropathy.【Methods】Fifty-eight IgA nephropathy patients were divided into two groups at random. The patients in test groupreceived leflunomide treatment; the patients in control group received fosinopril. Clinical data were observed andevaluated in the 2nd, 4th, 6th, 8th, 12th, 16th, 20th, 24th, and 28th weeks. 【Results】 After receivingleflunomide therapy, the proteinuria in the test group decreased significantly (P 0.05) ; serum albumin increasedsignificantly (P 0.05) . The complete relieving rate was 61%; the total efficient rate was 71%. Contracted with fosinopril, the efficiency of leflunomide on treating IgA nephropathy was not statistically different (P 0.05). Theside effects were mild, and all patients tolerated this the rapy.【Conclusion】Leflunomide is one of the choices in treating IgA nephropathy .

Key concepts: Leflunomide, Fosinopril, Medicine, Proteinuria, Nephropathy, Gastroenterology, Internal medicine, Urology

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