Clinical evaluation of efficacy and safety of intravenous ibutilide on patients with atrial fibrillation

Objective To observe converting efficacy and safety of intravenous ibutilide on atrial fibrillation patients.Methods 38 AF patients were divided into two groups,with 19 patients each.Patients of the group were treated with ibutilide and propafenone individually.Clinical efficacy were evaluated after 90 minutes and adverse reaction were observed after 24 hours of intravenous injection.Results Ibutilide had a higher cardioversion rate(57.89%) than propafenone(31.58%)with statistical significance(P0.05);The mean converting time of ibutilide group and propafenone group were(11.65±5.23) min and(26.21±13.89) min individually,and the former was significantly shorter than the latter(P0.05);The adverse reaction rate of ibutilide group was 5.26%,which was much lower than that of propafenone group(26.32%).Conclusion Ibutilide is allegro,effective and safety in converting atrial fibrillation.