Clinical efficacy and safety analysis of ibutilide and propafenone in the treatment of patients with atrial fibrillation

Objective To evaluate the clinical efficacy and safety of ibutilide and propafenone in the treatment of patients with atrial fibrillation. Methods A total of 66 patients with atrial fibrillation were included in this study. Of the recruited 66 subjects, 31 cases( experiment group) received ibutilide 1 mg by intravenous injection within 10 min and other 35 cases( control group) received propafenone70 mg by intravenous injection within 10 min. The treatment procedure were done again if the atrial fibrillation still existed after administration.The successful rate and adverse reactions were recorded in the two groups. Results The successful rate was 74. 2% in experiment group and 51. 4% in control group with statistical difference( P 0. 05). The median time of cardioversion was 20. 5 min for experiment group and25. 2 min in control group with significant difference( P 0. 05). The rate of adverse reactions were 29. 0% and 25. 7% in the treatment and control group,respectively without statistical difference( P 0. 05).Conclusion The successful rate of ibutilide in the treatment of patients with atrial fibrillation is relative higher with short period of time for success.