2010•Shiyong yaowu yu linchuangRequires access
Efficacy and safety of ibutilide for conversion of paroxysmal and persistent atrial fibrillation.
Li Tiejun, Yanli Chen, Xiaodong Li
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Abstract
Objective To evaluate the efficacy and safety of ibutilide for conversion of paroxysmal and persistent atrial fibrillation.Methods 43 patients with atrial fibrillation duration less than 90 days were included into propafenone or ibutilide group.23 patients were intravenously administrated with propafenone and 20 patients with ibutilide separately.Conversion rate,times needed to converse and adverse effects were compared between two groups.Results The total conversion rate of ibutilide group was significantly higher than that of propafenone group(70% vs 39.1%,P0.01).Both paroxysmal and persistent atrial fibrillation group patients showed higher conversion rate in ibutilide group[(76.9% vs 50%),(57.1% vs 27.3%),P0.05].Times needed to converse was significantly shortened of ibutilide group compared with propafenone group[(34.62±4.47)min vs(62.74±12.73)min,P0.01].No clinical significant adverse effects were observed in ibutilide group.Conclusion Intravenous administration of ibutilide in cardioversion of paroxysmal and persistent atrial fibrillation is more safe and effective than propafenone.