Relationship between GSTP1 genetic polymorphism and susceptibility of lung cancer in Xinjiang Uygurs and Hans

Objective To investigate the association between glutathione S-transferase P1(GSTP1) genetic polymorphism and lung cancer susceptibility in Xinjiang Uygurs and Hans.Methods PCR-restriction fragment length polymorphism(PCR-RFLP) analysis was used to detect the polymorphism of GSTP1 gene in 80 Uygur patients and 80 Han patients(case group),and 80 healthy Uygur subjects and 80 healthy Han subjects(control group).Difference in genotype frequencies between ethnic Uygurs and Hans was also analyzed.Results The genotype frequencies of GSTP1 gene rs1695 variants were in Hardy-Weinberg equilibrium in both case and control groups.In Uygur population,the genotype frequencies of GSTP1 at rs1695 site showed no significant difference between case and control groups(P 0.05).In Han population,there was significant difference between two groups(P 0.05).Han individuals with G allele had increased risk of developing lung cancer(OR = 2.170,95% CI:1.146 ~ 4.107,P 0.05).In both case and control groups,AG and GG genotype frequencies in Uygurs were higher than those in Hans.For control group,GG genotype frequency in Uygurs was1.3 times higher than that in Hans(8.8% vs 3.8%,P 0.05).Conclusion The genetic polymorphism of GSTP1 is associated with susceptibility to lung cancer in Han population,but not in Uygur population.