Xinjiang Uygurs and Hans A2M gene polymorphism analysis of Alzheimer's Disease

Objective To study the A2M gene polymorphism in Xinjiang Uygurs and Hans AD patients.Methods On the basis of epidemiological survey,209 cases of sporadic AD patients with average age(74.2 ± 12.6) years were randomly selected consisting of 111 cases of Uygur and Han 98 cases.Matched normal subjects 220 with the average age(73.8 ± 13.1) years including 117 cases of Uygur and Han 103 cases served as controls for the case-control study.A2M gene I1000V polymorphism was analyzed using restriction fragment length polymorphism methods.Results A2M-I1000V allele frequencies were 8.61% which was higher in AD group than 3.64% in control group(P0.05).The I/I genotype and the allele I frequency were higher in Han crowd than in the Uygur national minority.However,the I/V genotype and the allele V frequency in the Uygur national minority crowd was higher than in the Han Nationality(P0.05).The frequency of I/V genotype of A2M gene was higher in AD group than in control group among population without ApoEe4(P0.05).Conclusions AD is associated with A2MI100V polymorphism in both Xinjiang Uygur and Han nationalities and A2M genotype and allele frequency distribution is different between Xinjiang Uygur and Han nationalities.A2M might have a role in the development of AD independent of the ApoE e4.