Eradicating helicobacter pylori on healing and recurrence of peptic ulcer caused by nonsteroial antiinflammatory drug.

Objective To study the influence of eradicating helicobacter pylori(HP) on healing and recurrence of peptic ulcer cases with long-term use of nonsteroial antiinflammatory drug(NSAID).Methods 116 peptic ulcer cases taking long-term NSAID were divided into omeprazole group of Hp positive reaction(n = 43,omeprazole 20mg,two times a day),omeprazole plus amoxicillin group of Hp positive reaction(n = 38,omeprazole 20mg,two times a day;amoxicillin 0.5g,three times a day) and omeprazole group of Hp negative reaction(n =35,omeprazole 20mg,two times a day).Results Ulcer healing rates in three groups were 65%,74%,71% respectively(P 0.05).87 healed cases were divided into the eradicated Hp group(n = 26),HP lasting positive reaction group(n = 32) and Hp lasting negative reaction group(n = 29),and all the healed cases stopped peptic ulcer drug,but NSAID was taken continuously.73 cases were checked in 6 months,and u1cer recurrence rates in three healed groups were 31%,44%,29%,respectively(p 0.05).Conclusion Eradicating Hp can neither improve the ulcer healing rates nor reduce the recurrence rates.But the ulcer recurrence rates of Hp lasting position reaction show a tendency to increase.