Expressions of survivin and Ki67 in cervical carcinoma and their clinical signifcances

Objective To study the expressions of survivin and Ki67 in cervical carcinoma and explore the relation with the proliferation and apoptosis of cervical carcinoma. Methods Using immunohistochemical methods of SABC and SP. Results ①Expressions of survivin and Ki67 genes were detected in a significantly greater proportion of cervical carcinoma [ 69.6 %, (39/56); 82.1%,(46/56)] than adjacent normal cervical tissues[16.7%,(3/18)] ( P 0.01). ②There is no relationship between survivin gene expression and histological subtype or the tumor grade, otherwise, there is relationship between survivin gene expression and age, clinical stage, and lymph node metastasis. There is a relationship between Ki67 expression and clinical stage, no relationship between Ki67 expression and age, histological subtype, lymph node metastases or tumor grade. ③The expression of survivin gene is correlated with Ki67 expression. Conclusion There is a positive correlation between both abnormal expressions of survivin and Ki67 with cervical carcinoma.The occurrence of cervical carcinoma may be related with the cell apoptosis and proliferation.