Effects of Candesartan Cilexetil on Urine Microalbuminuria in Patients with Essential Hypertension

Objective To study the effects of Candesartan cilexetil on blood pressure and the urine microalbuminuria in patients with essential hypertension.Methods Eighty patients with essential hypertension were randomly divided into two groups.Candesartan cilexetil group(n=40) received Candesartan cilexetil 8～16mg/d for 12 weeks,and Captopril group(n=34) received captopril 37.5～150mg/d for 12 weeks.The serum creatinine,creatinine clearance rate and the urine microalbuminuria at the beginning and after 12 weeks of treatment were monitored.Results After treatment,blood pressure and the urine microalbuminuria significantly decreased in two groups(P0.01).There was no significant difference between Candesartan cilexetil group and Enalaprol group(P0.05).The serum creatinine and creatinine clearance rate had no significant difference between Candesartan cilexetil group and Captopril group(P0.05).The occurrence of cough in captopril group was 27.5%,3 patients discontinued Captopril therapy due to serious cough.There was no cough patient in Candesartan cilexetil group.Conclusion Candesartan cilexetil not only reduced blood pressure but also decreased the levers of urine microalbuminuria,and had same protection effects on renal function compared with Captopril.