Antihypertensive Effect and Renal Function Impact of Candesartan Cilexetil/Hydrochlorothiazide in Essential Hypertension Control Study

Objective: To evaluate the domestic Candesartan Cilexetil/Hydrochlorothiazide Capsules, with Candesartan Cilexetil Tablets as the positive control drug, for the curative effects on moderate primary hypertension and the influence on renal function. Methods: In our hospital, from December 2010 to February2012, 296 patients of primary hypertension were admitted, randomly divided into 2 groups and stopped other blood pressure medication for 2 weeks(cleaning period). In the control group, patients were given Candesartan Cilexetil Tablets(8 mg/tablet, p.o, 2 tablets once a day); in the experimental group, patients were given Candesartan Cilexetil/Hydrochlorothiazide Capsules(16 mg/12.5 mg/capsule, p.o, 1 capsule once a day). Before treatment and 4 and 8 weeks after treatment, patients were measured for blood pressure index,urinalysis, blood serum sodium, potassium, chloride, creatinine(Cr), creatinine clearance(Ccr) and urea nitrogen(BUN), etc. Results: After 8 weeks of treatment, the experimental group showed antihypertensive efficiency as 52.0% and total effective rate as 82.4%(n=148); The control group showed efficiency as 28.4%total effective rate as 28.4%(n =148); differences of efficiency and total effective rate between the two groups were statistically significant(P0.05). The results of urine and blood tests, between the treatment before and after, or between the two groups after treatment, showed no statistically significant differences(P0.05). Conclusion: Candesartan Cilexetil/Hydrochlorothiazide Capsules in patients with mild-to-moderate hypertension antihypertensive have effects superior to Candesartan Cilexetil Tablets with equivalent influence on renal functions.