CLINICAL COMPARISON ON THE CANDESARTAN CILEXETIL AND NIFEDIPINE IN TREATMENT WITH DIABETIC NEPHROPATHY WITH HYPERTENSION

[Objective]To compare the clinical effects of andesartan cilexetil and nifedipine in treatment with diabetic nephropathy with hypertension.[Methods]From December 2009 to December 2010,102 cases of diabetic nephropathy with hypertension patients were randomly separated into candesartan cilexetil group and nifedipine group,and each group had 51 cases.The observation group was treated with rosuvastatin at basis of normal therapy.The blood pressure and BUN,Cr before and after treatment were observed.[Results]Compared with pre-treatment,the levels of SBP and DBP were significantly decreased(P﹤0.05)in both two groups.There was no significant difference in the levels of SBP and DBP after treatment between both groups(P﹥0.05).Compared with pre-treatment,the levels of BUN and Cr were significantly decreased(P﹤0.05)in candesartan cilexetil group.The levels of BUN and Cr in candesartan cilexetil group were significantly lower than those in nifedipine group(P﹤0.05),while there was no significant difference before and after treatment in nifedipine group(P﹥0.05).[Conclusion]Both candesartan cilexetil and nifedipine in treatment with diabetic nephropathy with hypertension can low blood pressure,but candesartan cilexetil can protect kidney function,which can be applied in clinic.