Effect of vitamine E with tissue factor and tissue factor pathway inhibitor on coronary heart disease

Objective:The study was designed to discover the plasma levels of TF and TFPI in different type of coronary heart disease and to assess the efficacy of vitamine E in patients with acute myocardial infarction. Method: The plasma levels of TF and TFPI was assayed with ELISA method. The plasma concentration of TF and TFPI was measured in patients suffered from stable angina pectoris (SAP) group, unstable angina pectoris (UAP) group, acute myocardial infarction (AMI) group, and healthy subjects (control group). All patients were determined on immediate time and the second week after hospitalization. Result:①The plasma level of TF, TFPI and TF /TFPI ratio in SAP group was higher than that in control group, however the difference was not significant (P 0.05). Also, the change was so little with treatment (P 0.05).②The level of TF, TFPI and TF/TFPI ratio in UAP group and AMI group was much higher than that in control group significantly (P 0.01). There was still no change with usual therapy (P0.05). ③The level of TF in patients with AMI who were threated with vitamine E was decreased sharply on the second week (P 0.01) and was not significantly different with control group (P 0.05). The level of TFPI in the same patients didn't change respectively but TF/TFPI ratio was decreased significantly (P 0.01) during treatment. ④TF concentration correlated positively to TFPI concentration (P 0.05,r= 0.432). Conclusion:TF and TFPI are involved in the pathogenetic processes of coronary heart disease and play an important role in acute coronary syndrome. Vitamine E can decrease the level of TF, TF/TFPI ratio but not effect the level of TFPI.