Clinical significance of detecting the plasma levels of TF and TFPI in patients with acute leukemia

Objective:To detect the plasma levels of tissue factor(TF)and tissue factor pathway inhibitor(TFPI)in patients with acute leukemia(AL)and explore the clinical significance in the evaluation of development,curative effect and prognosis of AL patients through comparing the variation TF and TFPI levels in pre-treatment and post-chemotherapy.It can provid us the clinical diagnosis and treatment guideline through monitoring the changes of coagulation in AL patients.Methods:The levels of TF and TFPI were detected in the peripheral venous blood samples from 20 normal controls,and 48 newly diagnosed patients with acute leukemia(including 11 patients with acute lymphocytic leukemia(ALL),2 patients with M1,9 patients with M2,11 patients with M3,3 patients with M4,12 patients with M5),by enzyme linked immuno-sorbent assay(ELISA).Results:It was found TF and TFPI levels of post-chemotherapy were lower obviously than of pre-treatment.TF and TFPI levels in acute promyelocytic leukemia(APL) were higher significantly than those in patients with AL,except APL.In APL,the plasma levels of TF and TFPI after treatment were lower obviously than of pre-treatment.The plasma levels of TF and TFPI from AL patients with disseminated intravascular coagulation(DIC) were higher obviously than those in patients without DIC.In DIC group,the plasma levels of TF and TFPI before treatment were both higher significantly than those after treatment.Conclusions:The plasma levels of TF and TFPI in the newly diagnosed AL patients were higher obviously than those in the normal controls before treatment,but were lower obviously post-chemotherapy than of pre-treatment.It was shown they might participate in the evaluation of development,curative effect and prognosis of AL patients through comparing the variation TF and TFPI levels in pre-treatment and post-chemotherapy.The plasma levels of TF and TFPI reflect the development of diseases,there was a intimated correlation between the expression of TF和TFPI and DIC.In certain degree,TF and TFPI levels might be useful for the prediction of the curative effects of DIC.