Effect and mechanism of electro-acupuncture on behavioral recovery of chronic spinal cord injury rats

Objective To study the therapeutic mechanisms of electro-acupuncture on chronic spinal cord injury in rats.Methods According to the chronic progressive compressive spinal cord injury model of rats.45 wistar rats were divided into 3 groups:control group,SCI group and electro-acupuncture group.Each group 15 cases respectively.Hematoxylin-eosin staining,immunohistochemistry and TUENL methods were used to examine the expression of bax and bcl-2 in rats'spinal cord.The positive immunohistochemistry cells of bcl-2 and bax were observed by light microscope and analyzed by computer image analysis system.Results After electro-acupuncture,BBB was improved and the expression sequences of bcl-2 protein were observed more obvious than those in SCI group.On the contrary,the bax expresses obviously in the SCI group than those in the electro-acupuncture group.Conclusions The electro-acupuncture may increase synthesis of bcl-2 in spinal cord and facilitate the recovery of behavioral function of experimental animals.