2005•Journal of Shantou University Medical CollegeRequires access
Influence of Progressive Compression on the Behavioral Function and Expression of bcl-2 and bax in Chronic Spinal Cord Injury of Rats
Zhen Li
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Abstract
Objective:To study the changes of the expression of bcl_2 and bax in chronic spinal cord injury(SCI)of rats.Methods:According to the chronic progressive compressive spinal cord injury model of rats,30 Wistar rats were divided into control group and SCI group.Hematoxylin_eosin staining,immunohistochemistry and TUENL methods were used to examine the expression of bax and bcl_2 in rats' spinal cord. The positive immunohistochemistry cells of bcl_2 and bax were observed by light microscope and analyzed by computer image analysis system.Results:After spinal cord injury,CBS was increased and the expression sequences of bax protein in SCI group were observed more obvious than those in control group while the expression of bcl_2 no changed significantly. Conclusion:The progressive compression may increase synthesis of bax in spinal cord and inhibit the recovery of behavioral function of experimental animals.