Clinical Practice of ThinPrep Cytologic Test Combined with Colposcopy in Diagnosis of Cervical Lesions

Objective To study the clinical practice of ThinPrep cytologic test(TCT)combined with colposcopy in screening cervical lesions.Methods Cervical cytology screening was performed in 5,288 cases by TCT,and further biopsy under colposcopy was conducted on 210 positive cases.Results In 5,288 cases,99.0% of them were satisfactory,including 4,565 negative cases for intraepithelial lesion or malignancy,660 positive cases and 53 unsatisfied cases.In 210 positive cases,the positive rate of histology in squamous cells (62.25%,127/204) was higher than that in endocervical cells (33.33%,2/6),but no statistically significant difference was found (P0.05).The diagnostic accordance rate by TCT was 73.91%(17/23) for low-grade squamous intraepithelial lesion (LSIL),80.95% (34/42) for high-grade squamous intraepithelial lesion (HSIL),100%(1/1) for squamous cell carcinoma (SCC),respectively.The positive rate of cervical intraepithelial neoplasia and/or HPV infection in ASC-H cases was higher than that in ASC-US cases (P0.01).Conclusions TCT combined with colposcopy shows better clinical practice in diagnosis of squamous cell lesions than endocervical cells.Clinicians should give weight to unsatisfied smear,ASC-US,AGC as well as ASC-H.