Relationship between ambulatory pulse pressure and ventricular structure and function in hypertension patients with type 2 diabetes mellitus

Objective To investigate the characteristics of 24 h ambulatory pulse pressure of hypertension with or without type 2 diabetes mellitus(DM) and their correlation with ventricular structure and function. Methods All 215 patients were divided into type 2 DM( n =62),hypertension(EH, n =86), and hypertensive DM( n =67) groups.Echocardiogram and 24 h ambulatory blood pressure monitoring were observed in all patients. Results Twenty four hour systolic blood pressure(SBP 24 h),and 24 hour pulse pressure(PP 24 h) were significantly increased in hypertensive DM compared with type 2 DM or EH,indicating the left ventricular mass(LVM) was larger ( P 0.05).The percentage of cardiac systolic or diastolic dysfunction was significantly low in hypertensive DM compared with type 2 DM or EH.By regression analysis,LVM was related to PP24h in type 2 DM,SBP 24 h in EH,SBP 24 h and PP 24 h in hypertensive DM.SBP had marked impact on left ventricular systolic function. Conclusion Ambulary pulse pressure is an important factor predicting risk for ventricular hypertrophy and diastolic dysfunction in the patients with DM and EH.