A STUDY OF AMBULATORY PULSE PRESSURE AND HEART RATE VARIABILITY IN PATIENTS WITH ESSENTIAL HYPERTENSION AND DIABETES MELLITUS

Objective:To study the clinical significance of ambulatory pulse pressure (APP) and heart rate variability (HRV) in patients with essential hypertension (EH) and diabetes mellitus(DM).Methods:The APP and HRV of patients with EH(n=64),DM(n=26),EH+DM(n=30) and 43 mormal controls were compared.Results:①Compared with EH group and normal control group,the EH+DM group with APP≥50mmHg had higher percentages of patient?high age? LVH?abnormal ECG?CVD(P0 01).②Incidence rate of LVH?abnormal ECG and CVD in EH+DM group with APP≥50mmHg significantly increased than that in the group with APP50mmHg(P0 05).However no siginficant differences were found between the two groups in systolie pressure.diastolic pressure of 24h.③The real level of pulse pressure has a closer correlation with 24h mean pulse pressure than happening pulse pressure with it.④The HRV of EH and DM patients was lower than that of the normal controls,and that of EH+DM patients was the lowest.⑤The HRV im EH group and EH+DM group with APP≥50mmHg significantly decreased than that in the two groups with APP50mmHg.Conclusion:①Ambulatory pulse pressure is independent factors in predicting cardiac events of cardiovascular patients.②APP is more suitable for clinical study than happening pulse pressure.③The autonomic never system function of EH and DM patients are damaged,its damaged of EH+DM patients is the most.④APP is related to HRV.it can be useful to identify patients with high cardiovascular disease risk.