70 years old Effects of type 2 diabetes mellitus on ambulatory blood pressure and blood pressure variability in essential hypertensive patients

Objective To expiore the 70 years old effects of type 2 diabetes mellitus(T2DM) on ambulatory blood pressure(ABP) and blood pressure variability(BPV) in essential hypertensive(EH) patients.Methods Twenty-four-hour recordings of ambulatory biood pressure were performed in 74 EH patients and 74 EH patients with T2DM,and comparative analysis of ABP and BPV was made between the two groups.Results Mean daytime systolic blood pressure(dmSBP) and night systolic blood pressure(nmSBP)(P0.05 and 0.01),Mean daytime pulse pressure(dmPP) and night pulse pressure(nmPP) and 24h-pulse pressure(24h-mPP)(P0.05 and 0.01),daytime SBP standard deviation(dSBPSD) and its coefficient of variance(dSBPCV) and night SBP standard deviation(nSBPSD) and its coefficient of variance(nSBPCV) and 24h-SBP standard deviation(24h-SBPSD)(P0.05 and 0.01),of EH patients with T2DM were all significantly higher than those of EH patients without T2DM respectively.Conclusions T2DM could aggravate hypertension-induced ahnormality in both struoture and function of cardiovascular systems,and then increase ABP and BPV.Therefore improvement of insulin senoitivity in those EH subjects with impaired glucose metabolism might restore cardiovascular hemodynamics,thus stabilizing the blood pructuation and reducing ghe possibility of caediovasc complications.