Impact of Jiangzhi Mixture on Lipid Profile and Hemorheology of Hyperlipidemia Rats

Objective To observe the effect of Jiangzhi mixture on blood lipid profile and hemorheology of hyperlipidemia rats.Methods Sixty male Wistar rats were randomly divided into six groups,the normal control group,model group,simvastatin group,and high-,middle-,low-dose Jiangzhi mixture groups.The normal control group was fed with routine forage,and the other groups were fed with high fat forage for the establishment of hyperlipidemia model.During the modeling,the rats were given the corresponding drugs.After 10 weeks,we measured blood lipid profile and blood hemorheology of each rat.Results After treatment,serum total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),apolipoprotein B(ApoB) levels were decreased,and high density lipoprotein(HDL-C),apolipoprotein A(ApoA) levels and apoA / apoB ratio were increased in Jiangzhi mixture groups,the differences being statistically significan(t P 0.05 or P 0.01 compared with the model group).Jiangzhi mixture also had obvious effect on prolonging the time for arriving maximum oxidation rate(Tmax)and LDL oxidation lag time(Lag time),decreasing plasma viscosity(ηP),low-,medium-,and high-shear whole blood viscosity(ηb),index of erythrocyte aggregation(IEA),hematocri(t HCT),erythrocyte electrophoresis time(EET),and in-creasing the index of erythrocyte deformability(IED),the diff erences being statistically sig nifican(tP 0.05 or P 0.01 compared with the model group).Conclusion Jiangzhi mixture can modulate blood lipid metabolism,improve the viscosity,aggregation,and coagulation of hemorrheology,and reduce LDL susceptibility to oxidation in experimental hyperlipidemia rats,showing certain therapeutic effect on hyperlipidemia rats.