The correlation between coronary artery lesions of essential hypertension patients and their serum uric acid level

Objective To investigate the correlation between serum uric acid level and coronary artery lesions of essential hypertension patients. Methods The serum uric acid and other clinical biochemical parameters were measured in 367 essential hypertension patients who had undergone coronary angiography. According to the result of angiography, the patients were divided into coronary artery disease group(n=240)and normal coronary control group(n=128). Data of two groups were analyzed retrospectively. Results The level of serum uric acid was significant higher in coronary artery disease group than that in the control group [(448.32±115.12)μmol/L vs (371.36±98.98)μmol/L, P＜0.001]. Using stepwise regression analysis, a linear regression relationship was found between serum uric acid, LDL, blood glucose two hours after meal and severity of comoary lesions in essential hypertension patients. Conclusion Serum uric acid level had a strong correlation with severity of coronary lesions in essential hypertension patients. Whether lowering of serum uric acid lead to alleviation of coronary lesions is remained to be demonstrated by further prospective research.