Clinical study of hydroxycamptothecin(HCPT) combined with biweekly regimen of leucovorin,5-fluorouracil and oxaliplatin(FOLFOX4)in treatment of advanced gastrointestinal cancers

Objective To study the response and toxicity of the regimen of hydroxycamptothecin(HCPT) combined with biweekly regimen of leucovorin(CF),5-fluorouracil(5-FU) and oxaliplatin(L-OHP)(named FOLFOX4 regimen) in treat-ment of advanced gastrointestinal cancers.Mthods Twenty eight patients with advanced gastvointestinal cancer received chemotherapy of regimen L-OHP 80mg/m~2 2 hours iv on day1,CF 200 mg/m~2 2 hours iv on day 1to 2,followed by 5-FU 400 mg/m~2 iv and 600 mg/m~2 22 hours on day 1to 2.HCPT6 mg/m~2 iv 3 hours on day 1 to 3,two weeks as one cycle.Efficacy was evaluated after 4 cycles.Results Two patients achieved complete response(CR),16 patients partial response(PR),4 patients stable disease(SD),6 patients progression disease(PD).Overall response rate was 64.3%.Response rate was 68.8% in advanced gastric cancer.Response rate was 58.3% in advanced colorectal cancer.The major toxicity included nausea,vomiting,leucopenia and neuro-sensory.There were no any death during treatment.Conclusion This study shows that the regimen of HCPT combined with FOLFOX4 is effective and tolerable in advanced gastrointestinal cancer.