Clinical observation of oxaliplatin(L-OHP)combined with leucovorin,5-fluorouracil and hydroxycamptothecin(HCPT)for the treatment of patients with advanced colorectal cancer

Objective To observe the efficacy and toxic reaction of oxaliplatin(L-OHP)combined with hydroxycamptothecin(HCPT),leucovorin and 5-fluorouracil in the treatment of 31 patients with advanced colorectal cancer.Methods All patients were treated with L-OHP(150 mg/m~(2),ivgtt,d1)combined with leucovorin(100 mg/m~(2),ivgtt,d1 to d5),fluorouracil(500 mg/m~(2),ivgtt,d1 to d5)and HCPT(10 mg/m~(2),ivgtt,d1 to d5).The treatment was recycled every 21 days and finished after 2 recycles.Results Complete response was achieved in 2 cases,partial response in 10 cases,stable in 11cases and progression in 8 cases.The overall response rate was 38.7%.The main toxic reactions were myelosupression,nausea,vomiting(grade Ⅲ-Ⅳ 25.8%)and neuro-sensory toxicity(61.3%).Conclusion Oxaliplatin(L-OHP)combined with leucovorin,fluorouracil and hydroxycamptothecin(HCPT) regimen is effective in the treatment of advanced colorectal cancer and improves QOL.Its toxic effect is tolerable.