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Study On Quality Standard For Chongshen Xiaoyan Capsule

XU Ai-li

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Abstract

Objective:To establish the quality standard for chongshen xiaoyan capsule.Methods:Rhizoma Paridis,Radix Angelicae Sinensis and Radix Sophorae Flavescentis were identified by TLC;The content of matrine was determined by HPLC in this preparation.NUCLEOSIL-NH_2 column was used.The mobile phase was consisted of Acetonitrile-Ethanol-water wich 3% phosphoric acid(80∶10∶10).The flow rate was 1.0 mL·min~(-1) and column temperature was at 25 ℃.The detection wave length was at 220 nm.Results:The spots on TLC plates were clear without indeference in the blank reference.The linear range of matrine was(0.433 2)～(2.166 0 μg),r=(0.999 45.)The average recovery of matrine was 100.54% and RSD was 1.85%.Conclusion:The methods of identification and quantification is easy,accurate and reproducible.It can be used effectively for the quality control of this preparation.

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Objective:To establish the quality standard for chongshen xiaoyan capsule.Methods:Rhizoma Paridis,Radix Angelicae Sinensis and Radix Sophorae Flavescentis were identified by TLC;The content of matrine was determined by HPLC in this preparation.NUCLEOSIL-NH_2 column was used.The mobile phase was consisted of Acetonitrile-Ethanol-water wich 3% phosphoric acid(80∶10∶10).The flow rate was 1.0 mL·min~(-1) and column temperature was at 25 ℃.The detection wave length was at 220 nm.Results:The spots on TLC plates were clear without indeference in the blank reference.The linear range of matrine was(0.433 2)～(2.166 0 μg),r=(0.999 45.)The average recovery of matrine was 100.54% and RSD was 1.85%.Conclusion:The methods of identification and quantification is easy,accurate and reproducible.It can be used effectively for the quality control of this preparation.

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Available abstract

Objective:To establish the quality standard for chongshen xiaoyan capsule.Methods:Rhizoma Paridis,Radix Angelicae Sinensis and Radix Sophorae Flavescentis were identified by TLC;The content of matrine was determined by HPLC in this preparation.NUCLEOSIL-NH_2 column was used.The mobile phase was consisted of Acetonitrile-Ethanol-water wich 3% phosphoric acid(80∶10∶10).The flow rate was 1.0 mL·min~(-1) and column temperature was at 25 ℃.The detection wave length was at 220 nm.Results:The spots on TLC plates were clear without indeference in the blank reference.The linear range of matrine was(0.433 2)～(2.166 0 μg),r=(0.999 45.)The average recovery of matrine was 100.54% and RSD was 1.85%.Conclusion:The methods of identification and quantification is easy,accurate and reproducible.It can be used effectively for the quality control of this preparation.

Key concepts: Matrine, Quality standard, Chromatography, Phosphoric acid, Radix (gastropod), Capsule, Chemistry, High-performance liquid chromatography

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