Protective effects of Omeprazole on the toxic acute gastric mucosal lesion in rats

AIM:To study the protective effects of different doses Omeprazole on the toxic acute gastric mucosal lesion in rats.Meanwhile,the protective effects were investigated.METHODS:Forty rats were separated into blank control group,acute intoxication control group,low dose omeprazole treatment group,high dose omeprazole treatment group.Ulcer index was calculated,plasma ET,serum TNF-α and cholinesterase activity were measured.With gastric mucosa HE staining,gastric mucosa pathological changes were observed also.RESULTS:A toxic acute gastric mucosal lesion model were established on rats.Omeprazole could prevent rats from acute gastric mucosal lesion induced by poisoning,improve related indexes and pathological states as well;large dose omeprazole could be more beneficial for acute gastric mucosal lesion induced by poisoning.CONCLUSION:Administration of Omeprazole could improve the acute gastric mucosal lesion induced by orgnaophosphorus pesticide orally in rats,and large dose Omeprazole could be more beneficial;ET and TNF-α in serum could be considered as the surrogate for treatment of acute poisoning gastric mucosal lesion induced as well as index for early detection.