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An Experimental Study on Omeprazole in Preventing Gastric Mucosal Injury in Rats under Stress

LI Yu-me

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Abstract

Objective To evaluate the effect of omeprazole in preventing gastric mucosal injury in rats under stress. Methods Water immersion-restraint stress (WRS) model was performed in SD rats. One group were administrated with omeprazole as preventive measure, the other were not. The gastric mucosal ulcer index (UI) and gastric fluid PH value were detected, and the histological change and degree of injury of gastric mucosa were observed grossly and under light microscope. Results The decrease of UI and the increase of gastric fluid PH value in group with omeprazole were both significant compared to stress group without omeprazole (p0.01). Mucosal hyperaemia and edema but not hemorrhage and gastric ulcer could be observed in group with omeprazole under light microscope. Conclusions Omeprazole can restrain the gastric acid secretion, which can effectively prevent gastric mucosal injury in rats under stress.

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What this paper is about

Objective To evaluate the effect of omeprazole in preventing gastric mucosal injury in rats under stress. Methods Water immersion-restraint stress (WRS) model was performed in SD rats. One group were administrated with omeprazole as preventive measure, the other were not. The gastric mucosal ulcer index (UI) and gastric fluid PH value were detected, and the histological change and degree of injury of gastric mucosa were observed grossly and under light microscope. Results The decrease of UI and the increase of gastric fluid PH value in group with omeprazole were both significant compared to stress group without omeprazole (p0.01). Mucosal hyperaemia and edema but not hemorrhage and gastric ulcer could be observed in group with omeprazole under light microscope. Conclusions Omeprazole can restrain the gastric acid secretion, which can effectively prevent gastric mucosal injury in rats under stress.

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Available abstract

Objective To evaluate the effect of omeprazole in preventing gastric mucosal injury in rats under stress. Methods Water immersion-restraint stress (WRS) model was performed in SD rats. One group were administrated with omeprazole as preventive measure, the other were not. The gastric mucosal ulcer index (UI) and gastric fluid PH value were detected, and the histological change and degree of injury of gastric mucosa were observed grossly and under light microscope. Results The decrease of UI and the increase of gastric fluid PH value in group with omeprazole were both significant compared to stress group without omeprazole (p0.01). Mucosal hyperaemia and edema but not hemorrhage and gastric ulcer could be observed in group with omeprazole under light microscope. Conclusions Omeprazole can restrain the gastric acid secretion, which can effectively prevent gastric mucosal injury in rats under stress.

Key concepts: Omeprazole, Ulcer index, Hyperaemia, Stress ulcer, Medicine, Gastroenterology, Gastric mucosa, Edema

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