2000•PubMedRequires access

[Preventive effect of cardiomyopeptidin on rat heart injured by ischemia-reperfusion].

Yang Lp, Wan Hy, Kong Xp, Yanxia Wu, Jane Teng, Fan Ll

Abstract

OBJECTIVE: To investigate the preventive effect of cardiomyopeptidin of small molecular weight polypeptide on rat hearts injured by ischemia-reperfusion. METHODS: In a rat model injured by ischemia-reperfusion in the heart, observation was made on the influence of cardiomyopeptidin on the activities of creatine kinase (CK) and lactate dehydrogenase(LDH), as well as on the content of MDA in plasma after the preventive drug was used. RESULTS: Cardiomyopeptidin could obviously prevent the injury caused by ischemia-reperfusion, reduce the activities of CK and LDH and the content of MDA in a dose-dependent manner. CONCLUSION: Cardiomyopeptidin has a preventive effect on myocardium injured by ischemia-reperfusion and this may be related to its reducing the release of myocardial enzyme and anti-lipoperoxidation.

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Key concepts: Lactate dehydrogenase, Ischemia, Creatine kinase, Medicine, Pharmacology, Reperfusion injury, Myocardial ischemia, Anesthesia