2005•Unpublished venueRequires access

Protective effect of Ginaton on myocardial ischemia-reperfusion injury in rats

Jing Wen Fu

Abstract

ObjectiveTo investigate the influence of Ginaton on myocardial ischemia reperfusion injury in rat.MethodsThe myocardial ischemia-reperfusion model was induced by 10 min left anterior descending coronary occulusion and 30 min reperfusion in rats.The changes of myocardial infarct size(MIS),the serum creatine phosphokinase(CK),lactate lactate dehydrogenase(LDH),superoxide dismutase(SOD) activity,malondial dehyodebis(MDA) and occurrence ofarrhymia were investigated.ResultsIn rats treated by Ginaton,the MIS was significantly reduced,the serum CK and LDH activity declined,the serum SOD activity was increased markedly,the incidence of arrhymia declined.ConclusionConclusion Ginaton has protective effect on myocardial ischemia-reperfusion injury.

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Key concepts: Lactate dehydrogenase, Creatine kinase, Medicine, Reperfusion injury, Ischemia, Myocardial ischemia, Superoxide dismutase, Myocardial Reperfusion Injury