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2006•Zhongguo Yike Daxue xuebaoRequires access

Expressions of nerve growth factor and its receptors in salivary adenoid cystic carcinoma and their relationship with perineural invasion

Changfu Sun

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Abstract

Objective: To investigate the expressions of nerve growth factor (NGF) and its receptors, TrkA and p75NTR,in salivary adenoid cystic carcinoma (SACC) and their relationship with perineural invasion. Methods: The expressions of NGF, TrkA, and p75NTR in 21 cases of SACC and 8 normal salivary gland tissues were measured by using immunohistochemistry SABC method. Results: In normal salivary glands, no positive staining of NGF, TrkA, and p75NTR was found in the acinic cells, and the positive staining rate of NGF was 75% in ductal cells. In SACC, the positive staining rates of NGF and p75NTR were 81% and 76%, and no positive staining of TrkA was found. There was no significant difference in the expressions of NGF and p75NTR between SACC of different pathological types. Conclusion: NGF and p75NTR may play an important role in the infiltration and perineural invasion of SACC.

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Objective: To investigate the expressions of nerve growth factor (NGF) and its receptors, TrkA and p75NTR,in salivary adenoid cystic carcinoma (SACC) and their relationship with perineural invasion. Methods: The expressions of NGF, TrkA, and p75NTR in 21 cases of SACC and 8 normal salivary gland tissues were measured by using immunohistochemistry SABC method. Results: In normal salivary glands, no positive staining of NGF, TrkA, and p75NTR was found in the acinic cells, and the positive staining rate of NGF was 75% in ductal cells. In SACC, the positive staining rates of NGF and p75NTR were 81% and 76%, and no positive staining of TrkA was found. There was no significant difference in the expressions of NGF and p75NTR between SACC of different pathological types. Conclusion: NGF and p75NTR may play an important role in the infiltration and perineural invasion of SACC.

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Available abstract

Objective: To investigate the expressions of nerve growth factor (NGF) and its receptors, TrkA and p75NTR,in salivary adenoid cystic carcinoma (SACC) and their relationship with perineural invasion. Methods: The expressions of NGF, TrkA, and p75NTR in 21 cases of SACC and 8 normal salivary gland tissues were measured by using immunohistochemistry SABC method. Results: In normal salivary glands, no positive staining of NGF, TrkA, and p75NTR was found in the acinic cells, and the positive staining rate of NGF was 75% in ductal cells. In SACC, the positive staining rates of NGF and p75NTR were 81% and 76%, and no positive staining of TrkA was found. There was no significant difference in the expressions of NGF and p75NTR between SACC of different pathological types. Conclusion: NGF and p75NTR may play an important role in the infiltration and perineural invasion of SACC.

Key concepts: Nerve growth factor, Perineural invasion, Tropomyosin receptor kinase A, Adenoid cystic carcinoma, Pathology, Immunohistochemistry, Pathological, Staining

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