2009•Tianjin yiyaoRequires access
Expression and Significance of CK34βE12 and HSP27 in Papillary Thyroid Carcinoma
Huijuan Zhang
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Abstract
Objective:To investigate the expression and significance of CK34βE12 and HSP27 in papillary thyroid carcinoma(PTC).Methods:The expressions of CK34βE12 protein and HSP27 were examined by immunohistochemical staining using samples of 38 cases with PTC,10 cases with thyroid adenoma and 10 cases of normal thyroid tissue.Results:The positive expression rate of CK34βE12 was 42.10% in PTC compared with no expressions of CK34βE12 in normal thyroid tissue and thyroid adenoma(P = 0.004).There was no significant difference in expression rate of CK34βE12 between the patients with positive lymph node and with negative lymph node(P = 0.861).The positive expression rate of HSP27 was significantly higher in thyroid carcinoma(76.30%)than that in normal thyroid tissue(30.00%)and thyroid adenoma(40.00%,P = 0.017).The expression of HSP27 was higher in patients with positive lymph node than that with negative lymph node(P = 0.031).There was a positive relationship between the expressions of CK34βE12 and HSP27(rs = 0.494,P 0.05).Conclusion:The values of CK34βE12 and HSP27 may influence the development of PTC by regulating cell proliferation.The combined detection of CK34βE12 and HSP27 can be used as a reference marker in the differential diagnosis of benign and malignant disease,and evaluated the prognosis of PTC.