Application value of amniotle cell kargotyping in the prenatal diagnosis

Objective:To explore the use of amniocentesis in prenatal analysis,and reduce the newborn with abnormal chromosome.Methods:Amniocentesis was employed to detect amniotic cells collected from 320 pregnant women with high risk prenatal diagnosis indications.Results:Among the 320 pregnant women,315 cases amniotic fluid cells culture are successful,yield rate was 98.4%,thirteen fetus with chromosome abnormality were diagnosed by Karyotype analysis,of which,4 cases were trisomies(30.7%),two cases were sex chromosomal abnormalities(15%),4 cases were balanced translocations(30.7%),18 cases were chromosome polymorphism(5.6%).Conclusion:It′s necessary to examine the chromosome in fundamental hospital and importance for the diagnosis and treatment.Amniotic fluid culture for prenatal diagnosis is very safe and reliable.