161 cases of prenatal diagnosis by fetus cell karyotyping

Objective To analyze the detection rate and types of chromosomal abnormalities in prenatal diagnosis.Methods 161 cases of pregnant women with high risk results in prenatal screening or with other indications for prenatal diagnosis,were performed amniocentesis in 16~25 weeks of gestation,and followed by cell culture and G-banding karyotyping.Results 9 cases(5.6%) were detected with abnormal karyotypes,inluding 3 cases with heteromorphic chromosomes,3 cases with chromosome aneupoidies,and 3 cases with chromosome sructural abnormalities.All 3 cases of chromosome aneupoidies were Down's syndromes,of which all were detected because of high risk results in prenatal screening,and one case accompanied with pregnant age35.Conclusion Amniotic fluid cell culture and karyotyping are effective way for prenatal diagnosis in the woman with high risk.