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2004•Zhongguo haiyang yaowuRequires access

Protective effect of peptide S-8300 from shark liver on acute liver Injury in mice

Huang Feng

Open publisher page 6 citations

Abstract

Objective To study the hepatoprotective effect of peptide S 8300 from shark liver on CCl 4 induced liver injury in mice. Methods Mice were administered ip with three doses of S 8300 for four consecutive days, followed by CCl 4 ip on d3. The activity of SGPT, SGOT, LDH, and liver SOD as well as contents of MDA and GSH in the mice liver were tested. Results S 8300 can decrease obviously the levels of SGPT, SGOT, LDH activities and liver MDA content in liver injury mice caused by CCl 4 , increase SOD activities and the content of GSH of the liver. Conclusion S 8300 has significant protective effects on experimental liver injury mice.

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What this paper is about

Objective To study the hepatoprotective effect of peptide S 8300 from shark liver on CCl 4 induced liver injury in mice. Methods Mice were administered ip with three doses of S 8300 for four consecutive days, followed by CCl 4 ip on d3. The activity of SGPT, SGOT, LDH, and liver SOD as well as contents of MDA and GSH in the mice liver were tested. Results S 8300 can decrease obviously the levels of SGPT, SGOT, LDH activities and liver MDA content in liver injury mice caused by CCl 4 , increase SOD activities and the content of GSH of the liver. Conclusion S 8300 has significant protective effects on experimental liver injury mice.

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OpenAlex reports 6 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Objective To study the hepatoprotective effect of peptide S 8300 from shark liver on CCl 4 induced liver injury in mice. Methods Mice were administered ip with three doses of S 8300 for four consecutive days, followed by CCl 4 ip on d3. The activity of SGPT, SGOT, LDH, and liver SOD as well as contents of MDA and GSH in the mice liver were tested. Results S 8300 can decrease obviously the levels of SGPT, SGOT, LDH activities and liver MDA content in liver injury mice caused by CCl 4 , increase SOD activities and the content of GSH of the liver. Conclusion S 8300 has significant protective effects on experimental liver injury mice.

Key concepts: Liver injury, Glutathione, Liver tissue, Dose dependence, Peptide, Chemistry, Pharmacology, Endocrinology

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