Bacterial spectrum of 102 cases of bile culture and drug resistance

OBJECTIVE To analyze the main clinical symptoms and pathogenic bacteria of biliary infection,and their resistance to antibiotics.METHODS From Jan 2010 to Apr 2010,the bile of 102 cases obtained by ERCP were detected,culture the bile,the pathogenic bacteria causing biliary infection and their resistance to antibiotics were analyzed respectively.The relationship between biliary infection and the results of clinical symptom and lab results were also studied.RESULTS A total of 48 patients bile had bacteria,the positive rate was 47.06%.There were 54 strains bacteria.41 strains(75.93%) were Gram-negative bacilli and Gram-positive cocci accounted for 24.07%,Gram-negative bacilli were sensitive to amikacin sulfate,imipenem,ertapenem,meropenem and cefoperazone sodium and sulbactam sodium with low resistance rate.Gram-positive cocci were sensitive to imipenem,vancomycin,linezolid.Patients with fever and/or increasing leucocyte counts got more positive biliary culture than that of patients without fever and/or normal leucocyte count.But there was no significant difference in biliary culture between patients with abnormal liver function and normal liver function,the sensitivity rate was only 40.0%.CONCLUSION Among the pathogens of cholangitis,Gram-negative bacilli were most common,which are mostly sensitive to carbapenems,aminoglycoside and cefoperazone sodium and sulbactam sodium,while resistant to the carbostyril and 3rd generation cephems that are widely used clinically.