Clinical observation of mifepristone in treatment of uterine fibroids

Objective To evaluate the clinical efficacy and safety of mifepristone in the treatment of uterine fibroids. Methods The patients (48 cases) with uterine fibroids in September, 2011 to December, 2012 in Tianjin Central Obstetrics and Gynecology Hospital were retrospectively analyzed. The patients were po administered with mifepristone (10 mg/d) before bedtime from menstruation began to 3—5 d. Three months was as one course, and they were treated for one course. Uterine and fibroid volume, levels of estrogen and progesterone in serum were measured before and after the treatment. Results Uterine and fibroid volume, serum hormones and progesterone levels were of significant difference compared with those before the treatment (P 0.05). Conclusion The usage of mifepristone in the treatment of uterine myoma could effectively reduce the estrogen and progesterone levels in serum, and could reduce the size of uterus and myoma, which has the good effect on uterine symptoms of uterine fibroid.