The clinical significance of the blood LDH,β_2-MG,D-dimer measuring in the diagnosis and treatment of non-Hodgkin lymphoma

Objective To explore the clinical significance of the blood lactic dehydrogenase(LDH), β_2-microglobulin(β_2-MG),D-dimer measuring in the diagnosis and treatment of Non-Hodgkin lymphoma. Methods In 40 cases with NHL,LDH was measured by L-P continuous monitoring method,β_2-MG was measured by luminescent immunoassay,D-dimer was measured by immunoturbidimettic assay.Results The levels of the blood LDH,β_2-MG and D-dimer in patients with NHL were higher than those of in the controls(P 0.05),and the levels of Ⅲ～Ⅳ phase were significantly higher than those of Ⅰ～Ⅱ phase(P0.05),the lev- els of LDH,β_2-MG and D-dimer in patients of CR group after chemotherapy were normal(P0.05).Con- clusion The levels of blood LDH,β_2-MG,D-dimer can be taken as an auxiliary clinical index to diagnose, classify the phase,evaluate the effectiveness of treatment and prognosis in the NHL patients,and have impor- tant clinical significance.