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Effect of geniposide on serum IL-1β and TNF-α of rheumatoid arthritis rats

Wenjun Sun

Open publisher page 2 citations

Abstract

Objective: To study the effect of geniposide on serum IL-1β and TNF-αlevels of rheumatoid arthritis rats, as well as the mechanism of this drug. Method: To establish an experimental rat model of type Ⅱ collagen-induced arthritic (CIA). The inhibitory effects on paw edema were observed, and serum IL-1β and TNF-α levels were determined in experimental rats. Result: Compared with the model, geniposide delayed the starting time of right paw edema significantly, and the levels of serum IL-1β and TNF-α were significantly decreased by geniposide at high dose or medium dose(P0.01). Conclusion: Geniposide can lower serum IL-1β and TNF-α levels in rheuma-toid arthritis rats. The effect may be close related to inhibitory development of rheumatoid arthritis by the agent.

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What this paper is about

Objective: To study the effect of geniposide on serum IL-1β and TNF-αlevels of rheumatoid arthritis rats, as well as the mechanism of this drug. Method: To establish an experimental rat model of type Ⅱ collagen-induced arthritic (CIA). The inhibitory effects on paw edema were observed, and serum IL-1β and TNF-α levels were determined in experimental rats. Result: Compared with the model, geniposide delayed the starting time of right paw edema significantly, and the levels of serum IL-1β and TNF-α were significantly decreased by geniposide at high dose or medium dose(P0.01). Conclusion: Geniposide can lower serum IL-1β and TNF-α levels in rheuma-toid arthritis rats. The effect may be close related to inhibitory development of rheumatoid arthritis by the agent.

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Available abstract

Objective: To study the effect of geniposide on serum IL-1β and TNF-αlevels of rheumatoid arthritis rats, as well as the mechanism of this drug. Method: To establish an experimental rat model of type Ⅱ collagen-induced arthritic (CIA). The inhibitory effects on paw edema were observed, and serum IL-1β and TNF-α levels were determined in experimental rats. Result: Compared with the model, geniposide delayed the starting time of right paw edema significantly, and the levels of serum IL-1β and TNF-α were significantly decreased by geniposide at high dose or medium dose(P0.01). Conclusion: Geniposide can lower serum IL-1β and TNF-α levels in rheuma-toid arthritis rats. The effect may be close related to inhibitory development of rheumatoid arthritis by the agent.

Key concepts: Rheumatoid arthritis, Medicine, Tumor necrosis factor alpha, Arthritis, Pharmacology, Edema, Internal medicine, Endocrinology

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Effect of geniposide on serum IL-1β and TNF-α of rheumatoid arthritis rats — Research Paper | ScholarLens