Effect of glycyrrhizin on expression of TNF-α,IL-1 and IL-6 in adjuvant arthritis rat

Objective:To investigate the effect of glycyrrhizin on rat adjuvant arthritis serum TNF-α,IL-1 and IL-6 expression in an attempt to explore its treatment effect on adjuvant arthritis.Methods:An animal model of rheumatoid arthritis(AA) was established by the intradermal injection of 0.1mL Freund's complete adjuvant(CFA) into the rat right hind limb.At the 14th day after inflammation,rat secondary arthritis appeared.The AA rats in the treatment group received the intraperitoneal injection of glycyrrhizin injection 2mg/kg for 10 days,and at the 28th day all rats were killed.The levels of IL-1,IL-6 and TNF-αwere detected by ELISA.Results:The serum TNF-α,IL-1 and IL-6 levels of the treatment group were lower than those of the model group,and glycyrrhizin showed the inhibition on the serum TNF-α,IL-1 and IL-6 expression in rat adjuvant arthritis.Conclusion:Glycyrrhinzin can reduce the expression levels of the serum TNF-α,IL-1 and IL-6 in rat adjuvant arthritis,showing a certain role in the treatment of rheumatoid arthritis.