Efficacy and Safety of Rosuvastatin Calcium in Treatment of Elderly CHD Patients with Hyperlipidemia

Objective To observe the efficacy and safety of rosuvastatin calcium in treatment of elderly patients with coronary heart disease (CHD) complicated by hyperlipidemia.Methods One hundred twenty elderly CHD patients with hyperlipidemia were randomized into groups 5 mg,10 mg,20 mg,40 in each.All were given rosuvastatin calcium immediately after dinner,in doses of 5 mg,10 mg,20 mg,respectively,16 weeks.The lipid-lowering efficacy and safety were observed after 16 weeks.Results The levels of TC,TG,LDL-C decreased obviously in 3 groups,but more in 20mg group than in other 2 groups (P0.05).In 5 mg group,remarkable effectiveness was noted in 14 patients,effectiveness in 16,no effectiveness in 9,deterioration in 1;in 10 mg group,18,14,7,1,respectively;in 20 mg group,24,13,3,0,respectively,the difference was significant (Hc=6.522,P0.05).Group 20 mg was superior to groups 10 mg,5 mg in curative effect,the difference was significant (P0.05).The cholesterol meeting-standard rates of groups 5 mg,10 mg,20 mg were 60.0%,70.0%,87.5%,respectively,the difference was significant (P0.05).Conclusion Large dose Rosuvastatin Calcium,safe and with marked efficacy in treatment of elderly CHD with hyperlipidemia,is worth popularizing clinically.