Therapeutic effect of different dosages of metoprolol combined amiodarone on tachyarrhythmia

Objective:To compare clinical therapeutic effects of different dosages of metoprolol combined amiodarone on patients with tachyarrhythmia.Methods:A total of 120patients with tachyarrhythmia were randomly divided into small-dose group(n=40,received 5mg/d metoprolol),medium-dose group(n=40,received 10mg/d metoprolol)and large-dose group(n=40,received 15mg/d metoprolol)according to number table method.Each group received combined amiodarone therapy.Clinical indexes such as acting time,sinus rhythm conversion rate and left ventricular ejection fraction(LVEF)were compared among three groups.After three-month follow up,recurrence rate of tachyarrhythmia was compared among three groups.Results:Compared with small-dose group,there was significant reduction in acting time[(7.2±1.1)h vs.(3.4±1.0)h,(2.9±0.8)h],and significant rise in sinus rhythm conversion rate(57.5% vs.85.0%,90.0%)and effective rate(62.5% vs.90.0%,95.0%)in mediumdose group and large-dose group,P0.05or 0.01,but there were no significant difference between medium-dose group and large-dose group(P0.05all).There were no significant differences in mean blood pressure and heart rate,LVEF and incidence rates of all kinds of adverse reactions among three groups(P0.05).After three-month follow-up,recurrence rate of medium-dose group(2.5%)was significantly lower than those of large-dose group(10.0%)and small-dose group(20.0%),P0.05.Conclusion:Medium dosage of metoprolol combined with amiodarone possesses more clinical therapeutic effect than small-dose and large-dose in patients with tachyarrhythmia;it is worth extending in clinic.